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KMID : 0613820080180050738
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Journal of Life Science
2008 Volume.18 No. 5 p.738 ~ p.746
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Anti-HIV RNAs and Viral Vectors for Gene Therapy
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Park Jeong-Hae
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Abstract
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Human immunodeficiency virus (HIV) therapy has been in continuous development since the discovery of HIV. Various RNA genes to inhibit HIV replication have been deployed such as RNA decoy, antisense RNA, ribozyme, as well as conventional drugs that inhibit viral proteins. Small interfering RNAs (siRNAs) against HIV have been intensively studied as tools for HIV gene therapy in recent years and become powerful tools to block the replication of HIV. The RNA molecules against HIV is easy to manipulate and highly efficient inhibitors of HIV however the levels of expression and the delivery system of theses RNA genes against HIV should be carefully examined to introduce the therapeutic RNAs into target cells without inducing any toxicity. Due to frequent emergence of escape mutants, multiple approaches to block HIV replication should be considered and the development of different type of anti-HIV RNA technologies could contribute to an establishment of highly efficient combinational RNA therapy against HIV. This review will focus on the recent developments in potential target sites for therapeutic RNAs to block HIV and on the consideration of different types of anti-HIV RNAs and their expression units, as well as viral vectors to deliver these RNA genes to host cells.
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KEYWORD
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Human immunodeficiency virus gene therapy, viral vector, anti-HIV RNA, short hairpin RNAs, microRNAs
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